- U S Mint Independence Mall
- U-Haul Co
- Ubiq
- Uhuru Furniture & Collectibles
- Ultra Hair Studio
- Uncles
- Underground Station
- Unemployment Information Ctr
- Unica Inc
- Union Shoe Svc
- Unique Accessories
- Unique Design Two
- Unique Staffing Svc
- Uniquely Philadelphia Inc
- United Check Cashing Co
- United Health Group
- United Healthcare Svc
- United Paperworkers
- United Taekwon-Do Assn
- Unity
- Unity Enterprises Inc
- Univ Otorhinolaryngology Assoc
